Nitric oxide is involved in the regulation of angiogenesis
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چکیده
منابع مشابه
Is Nitric Oxide a Hormone?
Nitric oxide (NO) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. Recent evidences suggest that NO may act as an endocrine molecule. The aim of this review is considering available literature on endocrine roles of NO and/or its metabolites, i.e. nitrite and nitrate. Existing data suggest the idea that NO is a hormone that after production i...
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As tumors grow, their original vasculature can be insufficient to supply the growing tissue mass, and consequently local hypoxia develops. Thus neovascularisation is a key feature determining growth and metastasis of malignant tumors. This is, at least in part, mediated by humoral factors known to stimulate angiogenesis, such as vascular endothelial growth factor (VEGF) and fibroblast growth fa...
متن کاملNitric Oxide Mediates Angiogenesis
We evaluated the effects of nitric oxide (NO) generators and endogenous production of NO elicited by substance P (SP) in the angiogenesis process. Angiogenesis was monitored in the rabbit cornea in vivo and in vitro by measuring the growth and migration of endothelial cells isolated from coronary postcapillary venules. The angiogenesis promoted in the rabbit cornea by [Sari]-SP-sulfone, a stabl...
متن کاملNitric oxide and angiogenesis.
Endothelium-derived nitric oxide (NO) is a mediator of angiogenesis. Vascular endothelial growth factor (VEGF) stimulates the release of NO from cultured human umbilical venous endothelial cells and upregulates the expression of nitric oxide synthase (NOS).1,2 Segments of rabbit thoracic aorta release NO in response to VEGF; preincubation with L-arginine increases basal and VEGFstimulated NO re...
متن کاملIs there a role for nitric oxide in tumor angiogenesis?
In this issue of the Journal, Gallo et al. (1) report an interesting analysis of nitric oxide production and angiogenesis in head and neck cancers. They observed the following: 1) Tumor levels of total nitric oxide synthase activity (including inducible nitric oxide synthase activity) and of 38,58 cyclic guanosine monophosphate (cGMP) (a known mediator of cellular response to nitric oxide) were...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13476.x